Biology:CASP8AP2
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 Generic protein structure example |
CASP8-associated protein 2 is a protein that in humans is encoded by the CASP8AP2 gene.[1][2][3][4]
Function
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.[4]
Interactions
CASP8AP2 has been shown to interact with TRAF2.[5]
References
- ↑ "The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis". Nature 398 (6730): 777–85. Jun 1999. doi:10.1038/19709. PMID 10235259.
- ↑ "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies". EMBO J. 26 (2): 391–401. Jan 2007. doi:10.1038/sj.emboj.7601504. PMID 17245429.
- ↑ "FLASH is an essential component of Cajal bodies". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14802–7. Oct 2006. doi:10.1073/pnas.0604225103. PMID 17003126.
- ↑ 4.0 4.1 "Entrez Gene: CASP8AP2 CASP8 associated protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9994.
- ↑ "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. 276 (27): 25073–7. Jul 2001. doi:10.1074/jbc.M102941200. PMID 11340079.
Further reading
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. 2002. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "Apoptosis. Searching for FLASH domains". Nature 401 (6754): 662; discussion 662–3. 1999. doi:10.1038/44317. PMID 10537104.
- "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. 2000. doi:10.1093/dnares/7.1.65. PMID 10718198.
- "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. 276 (27): 25073–7. 2001. doi:10.1074/jbc.M102941200. PMID 11340079.
- "Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators". J. Biol. Chem. 278 (5): 3023–9. 2003. doi:10.1074/jbc.M209234200. PMID 12477726.
- "Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway". Oncogene 24 (4): 688–96. 2005. doi:10.1038/sj.onc.1208186. PMID 15592525.
- "FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors". J. Steroid Biochem. Mol. Biol. 92 (5): 357–63. 2004. doi:10.1016/j.jsbmb.2004.09.003. PMID 15698540. https://zenodo.org/record/1259189.
- "Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2". Blood 108 (3): 1050–7. 2006. doi:10.1182/blood-2006-01-0322. PMID 16627760.
- "FLASH is required for histone transcription and S-phase progression". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14808–12. 2006. doi:10.1073/pnas.0604227103. PMID 17003125.
- "Immunohistochemical and mutational analysis of FLASH in gastric carcinomas". APMIS 115 (8): 900–5. 2007. doi:10.1111/j.1600-0463.2007.apm_706.x. PMID 17696945.
External links
- CASP8AP2 human gene location in the UCSC Genome Browser.
- CASP8AP2 human gene details in the UCSC Genome Browser.
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