Biology:CASP8AP2

From HandWiki
A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

CASP8-associated protein 2 is a protein that in humans is encoded by the CASP8AP2 gene.[1][2][3][4]

Function

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.[4]

Interactions

CASP8AP2 has been shown to interact with TRAF2.[5]

References

  1. "The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis". Nature 398 (6730): 777–85. Jun 1999. doi:10.1038/19709. PMID 10235259. 
  2. "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies". EMBO J. 26 (2): 391–401. Jan 2007. doi:10.1038/sj.emboj.7601504. PMID 17245429. 
  3. "FLASH is an essential component of Cajal bodies". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14802–7. Oct 2006. doi:10.1073/pnas.0604225103. PMID 17003126. 
  4. Jump up to: 4.0 4.1 "Entrez Gene: CASP8AP2 CASP8 associated protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9994. 
  5. "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. 276 (27): 25073–7. Jul 2001. doi:10.1074/jbc.M102941200. PMID 11340079. 

Further reading

External links