Biology:CATSPERQ

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Cation channel sperm-associated auxiliary subunit theta is a protein that in humans is encoded by the CATSPERQ gene (previously TMEM249). The CATSPERQ protein is part of the CatSper complex which is involved in the movement of sperm (in particular hyperactivation).

Locus

CATSPERQ is located near the end of the long arm of chromosome 8 in humans.

General position of CATSPERQ on human chromosome 8 marked by a red line.

Common aliases

CATSPERQ is also known as TMEM249 or C8orfk29.

Primary sequence and variants or isoforms

Isoforms and splice variants of CATSPERQ provided by NCBI's Aceview and Softberry

The primary sequence found at NCBI and Aceview on NCBI predicts there are five spliceforms, with four closely resembling one another and the fifth missing a large 5' intron region. Softberry reinforces the Aceview data by predicting five exons, which are seen in four of the five spliceforms of Aceview.

The general structure of the CATSPERQ transcript has a large 5' UTR followed by exon 1, then a large intron followed by exon 2, a small intron then exon 3. The rest of the protein follows exon 3 with a large intron, exon 4 a small intron then exon 5, the 3' UTR.

The primary transcript contains all five exons and produces a protein that is 235 amino acids long. Transcript 1 and 2 are translated in the 3' to 5' direction while transcripts 3 through 5 are translated in the 5' to 3' direction. The gene is encoded on the minus strand within the chromosome.

Further reading

• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. December 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.