Biology:CCDC90B
 Generic protein structure example |
Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene.
Gene
CCDC90B is located on chromosome 11 in humans. It is neighbored by:[1]
- PCF11, a mammalian pre-mRNA cleavage complex 2 protein
- ANKRD42, ankyrin repeat protein involved with calcium ion bonding
- BC070093
- DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family
Protein
Structure
This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.
The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.
Predicted Properties
Molecular Weight: 26.72 kDa
Isoelectric point: 7.5
Transmembrane Helices: None
Post-translation modifications:[2]
- Chloroplast transit peptides: None
- Signal pepties: None
- C-mannosylation sites: None
- N-glycosylation sites: None
- Mitochondrial targeting: Yes
- Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP
Cellular Location
CCDC90B is presumably a mitochondrial protein. It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.
References
- ↑ "UCSC Genome Bioinformatics BLAT". University of California - Santa Cruz. March 2006. http://genome.ucsc.edu/cgi-bin/hgTracks?position=chr11:82650154-82675025&db=hg18&ss=../trash/hgSs/hgSs_genome_3acd_c806a0.pslx+../trash/hgSs/hgSs_genome_3acd_c806a0.fa&hgsid=132301808. Retrieved 2009-05-14.
- ↑ "ExPASy". SIB Switzerland. 2009-01-05. http://www.expasy.ch/. Retrieved 2009-05-14.
External links
- Human CCDC90B genome location and CCDC90B gene details page in the UCSC Genome Browser.
 |  |
