Biology:CCDC90B
Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene. It is a mitochondrial calcium uniporter binding protein.[1]
Gene
CCDC90B is located on chromosome 11 in humans. It is neighbored by:[2]
- PCF11, a mammalian pre-mRNA cleavage complex 2 protein
- ANKRD42, ankyrin repeat protein involved with calcium ion bonding
- BC070093
- DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family
Structure
This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.
The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.
Properties
- Molecular Weight: 26.72 kDa
- Isoelectric point: 7.5
- Transmembrane Helices: None
Post-translation modifications:[3]
- Chloroplast transit peptides: None
- Signal pepties: None
- C-mannosylation sites: None
- N-glycosylation sites: None
- Mitochondrial targeting: Yes
- Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP
It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.
References
- ↑ "Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles". Structure 27 (3): 464–475.e6. March 2019. doi:10.1016/j.str.2018.11.004. PMID 30612859.
- ↑ "UCSC Genome Bioinformatics BLAT". University of California - Santa Cruz. March 2006. http://genome.ucsc.edu/cgi-bin/hgTracks?position=chr11:82650154-82675025&db=hg18&ss=../trash/hgSs/hgSs_genome_3acd_c806a0.pslx+../trash/hgSs/hgSs_genome_3acd_c806a0.fa&hgsid=132301808.
- ↑ "ExPASy". SIB Switzerland. 2009-01-05. http://www.expasy.ch/.
External links
- Human CCDC90B genome location and CCDC90B gene details page in the UCSC Genome Browser.
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