Biology:CCT3
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T-complex protein 1 subunit gamma is a protein that in humans is encoded by the CCT3 gene.[1][2]
Function
This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
Interactions
CCT3 has been shown to interact with PPP4C.[3][4]
References
- ↑ "cDNA encoding a novel TCP1-related protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1217 (2): 224–6. Mar 1994. doi:10.1016/0167-4781(94)90041-8. PMID 8110840.
- ↑ 2.0 2.1 "Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7203.
- ↑ "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry 283 (43): 29273–84. Oct 2008. doi:10.1074/jbc.M803443200. PMID 18715871.
- ↑ "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics 4 (11): 1725–40. Nov 2005. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
External links
- Human CCT3 genome location and CCT3 gene details page in the UCSC Genome Browser.
Further reading
- "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology 4 (2): 89–99. Feb 1994. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
- "Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization". Genomics 22 (3): 634–6. Aug 1994. doi:10.1006/geno.1994.1438. PMID 8001976.
- "Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma". The Biochemical Journal 313 (Pt 2): 381–9. Jan 1996. doi:10.1042/bj3130381. PMID 8573069.
- "Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC". Molecular Cell 4 (6): 1051–61. Dec 1999. doi:10.1016/S1097-2765(00)80233-6. PMID 10635329.
- "Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression". Journal of Hepatology 38 (3): 298–306. Mar 2003. doi:10.1016/S0168-8278(02)00412-9. PMID 12586295.
- "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics 81 (2): 112–25. Feb 2003. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
- "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research 289 (2): 211–21. Oct 2003. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
- "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry 278 (51): 51901–10. Dec 2003. doi:10.1074/jbc.M309655200. PMID 14532270.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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