Biology:CDC16
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.[1][2]
Function
This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]
Interactions
CDC16 has been shown to interact with CDC27[3][4][5][6] and CDC20.[3][5][7][8]
References
- ↑ "CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition". Cell 81 (2): 261–8. Apr 1995. doi:10.1016/0092-8674(95)90336-4. PMID 7736578.
- ↑ 2.0 2.1 "Entrez Gene: CDC16 cell division cycle 16 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8881.
- ↑ 3.0 3.1 "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology 13 (17): 1459–68. Sep 2003. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. Bibcode: 2003CBio...13.1459V.
- ↑ "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". The Journal of Biological Chemistry 272 (51): 32011–8. Dec 1997. doi:10.1074/jbc.272.51.32011. PMID 9405394.
- ↑ 5.0 5.1 "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". The Journal of Cell Biology 141 (6): 1393–406. Jun 1998. doi:10.1083/jcb.141.6.1393. PMID 9628895.
- ↑ "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America 97 (16): 8973–8. Aug 2000. doi:10.1073/pnas.97.16.8973. PMID 10922056. Bibcode: 2000PNAS...97.8973G.
- ↑ "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". The Journal of Cell Biology 158 (5): 841–7. Sep 2002. doi:10.1083/jcb.200201135. PMID 12196507.
- ↑ "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nature Cell Biology 10 (12): 1411–20. Dec 2008. doi:10.1038/ncb1799. PMID 18997788.
External links
- Human CDC16 genome location and CDC16 gene details page in the UCSC Genome Browser.
Further reading
- "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". The Journal of Biological Chemistry 272 (51): 32011–8. Dec 1997. doi:10.1074/jbc.272.51.32011. PMID 9405394.
- "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science 279 (5354): 1219–22. Feb 1998. doi:10.1126/science.279.5354.1219. PMID 9469815. Bibcode: 1998Sci...279.1219Y.
- "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". The Journal of Cell Biology 141 (6): 1393–406. Jun 1998. doi:10.1083/jcb.141.6.1393. PMID 9628895.
- "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry 274 (20): 14500–7. May 1999. doi:10.1074/jbc.274.20.14500. PMID 10318877.
- "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC". The Journal of Cell Biology 146 (5): 941–54. Sep 1999. doi:10.1083/jcb.146.5.941. PMID 10477750.
- "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proceedings of the National Academy of Sciences of the United States of America 96 (20): 11317–22. Sep 1999. doi:10.1073/pnas.96.20.11317. PMID 10500174. Bibcode: 1999PNAS...9611317G.
- "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America 97 (16): 8973–8. Aug 2000. doi:10.1073/pnas.97.16.8973. PMID 10922056. Bibcode: 2000PNAS...97.8973G.
- "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene 262 (1–2): 51–9. Jan 2001. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. Sep 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes & Development 15 (21): 2822–36. Nov 2001. doi:10.1101/gad.912901. PMID 11691834.
- "TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas". Hepatology 35 (6): 1476–84. Jun 2002. doi:10.1053/jhep.2002.33683. PMID 12029633.
- "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". The Journal of Cell Biology 158 (5): 841–7. Sep 2002. doi:10.1083/jcb.200201135. PMID 12196507.
- "Alterations of anaphase-promoting complex genes in human colon cancer cells". Oncogene 22 (10): 1486–90. Mar 2003. doi:10.1038/sj.onc.1206224. PMID 12629511.
- "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology 13 (17): 1459–68. Sep 2003. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. Bibcode: 2003CBio...13.1459V.
- "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". The EMBO Journal 22 (24): 6598–609. Dec 2003. doi:10.1093/emboj/cdg627. PMID 14657031.
- "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. Apr 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
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