Biology:CDCA8
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Borealin is a protein that in humans is encoded by the CDCA8 gene.[1][2][3]
Function
CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[3][4]
Interactions
CDCA8 has been shown to interact with INCENP,[4] Survivin[2][4] and Aurora B kinase.[2][4]
References
- ↑ "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets 1 (1): 73–83. May 2001. doi:10.2174/1568009013334241. PMID 12188893.
- ↑ 2.0 2.1 2.2 "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell 118 (2): 187–202. Jul 2004. doi:10.1016/j.cell.2004.06.026. PMID 15260989.
- ↑ 3.0 3.1 "Entrez Gene: CDCA8 cell division cycle associated 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55143.
- ↑ 4.0 4.1 4.2 4.3 "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology 166 (2): 179–91. Jul 2004. doi:10.1083/jcb.200404001. PMID 15249581.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Proteome analysis of the human mitotic spindle". Molecular & Cellular Proteomics 4 (1): 35–43. Jan 2005. doi:10.1074/mcp.M400158-MCP200. PMID 15561729.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. Jan 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody". EMBO Reports 7 (1): 85–92. Jan 2006. doi:10.1038/sj.embor.7400562. PMID 16239925.
- "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis". The Journal of Biological Chemistry 281 (2): 1286–95. Jan 2006. doi:10.1074/jbc.M508773200. PMID 16291752.
- "Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer". Experimental Cell Research 312 (7): 962–73. Apr 2006. doi:10.1016/j.yexcr.2005.12.015. PMID 16427043.
- "Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres". Molecular Biology of the Cell 17 (4): 1897–909. Apr 2006. doi:10.1091/mbc.E05-08-0727. PMID 16436504.
- "Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown". Oncogene 25 (35): 4867–79. Aug 2006. doi:10.1038/sj.onc.1209499. PMID 16547492.
- "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. Apr 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP". Molecular Biology of the Cell 17 (6): 2547–58. Jun 2006. doi:10.1091/mbc.E05-12-1133. PMID 16571674.
- "Analysis of mitotic phosphorylation of borealin". BMC Cell Biology 8: 5. 2007. doi:10.1186/1471-2121-8-5. PMID 17241471.
- "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis". Cancer Research 67 (9): 4113–22. May 2007. doi:10.1158/0008-5472.CAN-06-4705. PMID 17483322.
External links
- Human CDCA8 genome location and CDCA8 gene details page in the UCSC Genome Browser.
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