Biology:CEP170

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.

Function

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 (Cdk1) and polo-like kinase 1 (PLK1), and functions in maintaining microtubule organization, cell morphology and cilium stability.

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.

External links

• Human CEP170 genome location and CEP170 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 170 kDa (CEP170)

Further reading

• "Proteomic characterization of the human centrosome by protein correlation profiling.". Nature 426 (6966): 570–4. 2003. doi:10.1038/nature02166. PMID 14654843. Bibcode: 2003Natur.426..570A. 
• "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
• "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.". Mol. Biol. Cell 16 (3): 1095–107. 2005. doi:10.1091/mbc.E04-10-0939. PMID 15616186. 
• "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. 2005. doi:10.1021/pr050048h. PMID 16083285. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Lamla S (2009). Functional characterisation of the centrosomal protein Cep170. Dissertation, LMU Muenchen: Fakultät für Biologie (Text.PhDThesis). URN nbn:de:bvb:19-97838.