Biology:CIDEB
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cell death-inducing DFFA-like effector b, also known as CIDEB, is a human gene.[1][2][3]
In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease.[4] CIDEB knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis. The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis. In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.[5] CIDEB plays a key role in determining lipid droplet size: overexpression of CIDEB in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets.[6][4]
References
- ↑ "Entrez Gene: CIDEB cell death-inducing DFFA-like effector b". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27141.
- ↑ Ye, Jing; Zhong Li, John; Liu, Yang; Li, Xuanhe; Yang, Tianshu; Ma, Xiaodong; Li, Qing; Yao, Zemin et al. (2009). "Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B.". Cell Metabolism 9 (2): 177–190. doi:10.1016/j.cmet.2008.12.013. PMID 19187774.
- ↑ Li, JZ; Lei, Y; Wang, Y; Zhang, Y; Ye, J; Xia, X; Pan, X; Li, P (May 2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta 1801 (5): 577–86. doi:10.1016/j.bbalip.2010.01.012. PMID 20123130.
- ↑ 4.0 4.1 Verweij, Niek; Haas, Mary E.; Nielsen, Jonas B.; Sosina, Olukayode A.; Kim, Minhee; Akbari, Parsa; De, Tanima; Hindy, George et al. (2022-07-28). "Germline Mutations in CIDEB and Protection against Liver Disease". New England Journal of Medicine 387 (4): 332–344. doi:10.1056/NEJMoa2117872. ISSN 0028-4793. PMID 35939579. https://doi.org/10.1056/NEJMoa2117872.
- ↑ Zhong Li, John; Ye, Jing; Xue, Bofu; Qi, Jingzong; Zhang, Jing; Zhou, Zhihong; Li, Qing; Wen, Zilong et al. (2007). "Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogeneis and fatty acid oxidation". Diabetes 56 (10): 2523–2532. doi:10.2337/db07-0040. PMID 17646209. http://diabetes.diabetesjournals.org/cgi/content/short/56/10/2523.
- ↑ Xu, Wenyi; Wu, Lizhen; Yu, Miao; Chen, Feng-Jung; Arshad, Muhammad; Xia, Xiayu; Ren, Hao; Yu, Jinhai et al. (2016-02-26). "Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes". The Journal of Biological Chemistry 291 (9): 4282–4293. doi:10.1074/jbc.M115.701094. ISSN 1083-351X. PMID 26733203.
Further reading
- "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.". EMBO J. 17 (9): 2526–33. 1998. doi:10.1093/emboj/17.9.2526. PMID 9564035.
- "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis.". Cell 99 (7): 747–55. 2000. doi:10.1016/S0092-8674(00)81672-4. PMID 10619428.
- "Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis.". J. Biol. Chem. 275 (30): 22619–22. 2000. doi:10.1074/jbc.C000207200. PMID 10837461.
- "Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family.". Biochem. J. 370 (Pt 1): 195–203. 2003. doi:10.1042/BJ20020656. PMID 12429024.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis.". J. Biol. Chem. 278 (20): 18256–64. 2003. doi:10.1074/jbc.M209732200. PMID 12595532.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene.". Biochem. J. 393 (Pt 3): 779–88. 2006. doi:10.1042/BJ20051027. PMID 16248853.
- "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta 1801 (Pt 5): 577–586. 2010. doi:10.1016/j.bbalip.2010.01.012. PMID 20123130.
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