Biology:CIZ1

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Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.[1][2]

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.[2]

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.[3]

Ciz1 mutant mice

Aged (18-mo-old) Ciz1-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.[4] Embryonic fibroblasts from Ciz1-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.[4]

Interactions

CIZ1 has been shown to interact with P21.[1]

References

  1. ↑ 1.0 1.1 "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochemical and Biophysical Research Communications 264 (2): 457–64. October 1999. doi:10.1006/bbrc.1999.1516. PMID 10529385. 
  2. ↑ 2.0 2.1 "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=25792. 
  3. ↑ "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proceedings of the National Academy of Sciences of the United States of America 109 (45): E3128-35. November 2012. doi:10.1073/pnas.1210107109. PMID 23074256. 
  4. ↑ 4.0 4.1 "DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice". Neurobiology of Aging 62: 180–190. February 2018. doi:10.1016/j.neurobiolaging.2017.10.014. PMID 29154038. 

Further reading

  • "Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog". The FEBS Journal 275 (2): 332–40. January 2008. doi:10.1111/j.1742-4658.2007.06203.x. PMID 18081865. 
  • "Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1". Human Mutation 28 (10): 993–1004. October 2007. doi:10.1002/humu.20550. PMID 17508423. 
  • "Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action". Cancer Research 66 (22): 11021–9. November 2006. doi:10.1158/0008-5472.CAN-06-2336. PMID 17108141. 
  • "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • "Ciz1 promotes mammalian DNA replication". Journal of Cell Science 118 (Pt 1): 101–12. January 2005. doi:10.1242/jcs.01599. PMID 15585571. 
  • "Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC". Journal of Biomedical Science 10 (4): 406–17. 2004. doi:10.1159/000071160. PMID 12824700. 
  • "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Human Molecular Genetics 8 (7): 1313–20. July 1999. doi:10.1093/hmg/8.7.1313. PMID 10369878. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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