Biology:CKAP2

Short description: Protein-coding gene in humans

Generic protein structure example

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.

Human CKAP2 gene, the cDNA of which is known as LB1, is a cytoskeleton-associated protein involved in mitotic progression. Its high transcriptional activity has been observed in the testes, thymus, and diffuse B-cell lymphomas. The gene codes for a protein of 683 residues, which lacks a homology to known amino acid sequences. On evidence of immunofluorescence analysis, the CKAP2 product is a cytoplasmic protein associated with cytoskeletal fibrils. The CKAP2 gene is in chromosome 13q14. Rearrangements of this region result in various tumors. Thus deletions have been detected in multiple myeloma, prostate cancer, head-and-neck squamous-cell carcinoma, B-cell prolymphocytic leukemia, non-Hodgkin lymphoma, and in more than half cases of B-cell chronic lymphocytic leukemia.

References

Alternative titles: tumor- and microtubule-associated protein; TMAP, LB1

External links

• Human CKAP2 genome location and CKAP2 gene details page in the UCSC Genome Browser.

Further reading

• "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. 2001. doi:10.1073/pnas.021386498. PMID 11149944. 
• "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Evolutionarily-conserved gene CKAP2, located in region 13q14.3 of the human genome, is frequently rearranged in various tumors". Genetika 37 (1): 120–3. 2001. PMID 11234418. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "[The structure of the human oncogenesis-associated CKAP2 (LB1) gene]". Mol. Biol. (Mosk.) 36 (6): 985–9. 2003. PMID 12500535. 
• "Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas". J. Cancer Res. Clin. Oncol. 129 (11): 621–30. 2004. doi:10.1007/s00432-003-0484-0. PMID 12942315. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. 2004. doi:10.1038/nature02379. PMID 15057823. Bibcode: 2004Natur.428..522D. 
• "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660. Bibcode: 2004CBio...14.1436J. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N. 
• "A cytoskeleton-associated protein, TMAP/CKAP2, is involved in the proliferation of human foreskin fibroblasts". Biochem. Biophys. Res. Commun. 348 (1): 222–8. 2006. doi:10.1016/j.bbrc.2006.07.046. PMID 16876122. 
• "Functional Importance of the Anaphase-Promoting Complex-Cdh1-Mediated Degradation of TMAP/CKAP2 in Regulation of Spindle Function and Cytokinesis". Mol. Cell. Biol. 27 (10): 3667–81. 2007. doi:10.1128/MCB.01386-06. PMID 17339342. 
• "CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit". J. Biol. Chem. 282 (20): 15103–13. 2007. doi:10.1074/jbc.M701688200. PMID 17376772.