Biology:CMAS (gene)
 Generic protein structure example |
N-acylneuraminate cytidylyltransferase is an enzyme that in humans is encoded by the CMAS gene.[1][2][3]
Function
The enzyme encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.[3]
References
- ↑ "Generation and analysis of 280,000 human expressed sequence tags". Genome Research 6 (9): 807–28. September 1996. doi:10.1101/gr.6.9.807. PMID 8889549.
- ↑ "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature 377 (6547 Suppl): 3–174. September 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.
- ↑ 3.0 3.1 "Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55907.
External links
- Human CMAS genome location and CMAS gene details page in the UCSC Genome Browser.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs". Proceedings of the National Academy of Sciences of the United States of America 95 (16): 9140–5. August 1998. doi:10.1073/pnas.95.16.9140. PMID 9689047. Bibcode: 1998PNAS...95.9140M.
- "A second uniquely human mutation affecting sialic acid biology". The Journal of Biological Chemistry 276 (43): 40282–7. October 2001. doi:10.1074/jbc.M105926200. PMID 11546777.
- "Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells". Glycoconjugate Journal 18 (3): 205–13. March 2001. doi:10.1023/A:1012452705349. PMID 11602804.
- "Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity". The Journal of Biological Chemistry 277 (22): 19688–96. May 2002. doi:10.1074/jbc.M201093200. PMID 11893746.
- "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research 30 (14): 3163–70. July 2002. doi:10.1093/nar/gkf428. PMID 12136098.
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