Biology:CORO2A

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].

External links

• Human CORO2A genome location and CORO2A gene details page in the UCSC Genome Browser.

Further reading

• "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal 22 (6): 1336–46. March 2003. doi:10.1093/emboj/cdg120. PMID 12628926. 
• "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell 12 (3): 723–34. September 2003. doi:10.1016/j.molcel.2003.08.008. PMID 14527417. 
• "Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway". Journal of Cell Science 122 (Pt 17): 3061–9. September 2009. doi:10.1242/jcs.051482. PMID 19654210. 
• "Common variants in FOXP1 are associated with generalized vitiligo". Nature Genetics 42 (7): 576–8. July 2010. doi:10.1038/ng.602. PMID 20526340. 
• "cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region". DNA and Cell Biology 15 (12): 1049–56. December 1996. doi:10.1089/dna.1996.15.1049. PMID 8985118.