Biology:CPEB1
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 Generic protein structure example |
Cytoplasmic polyadenylation element-binding protein 1 is a protein that in humans is encoded by the CPEB1 gene.[1][2]
This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
References
- ↑ "Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein". Gene 263 (1–2): 113–20. Mar 2001. doi:10.1016/S0378-1119(00)00588-6. PMID 11223249.
- ↑ 2.0 2.1 "Entrez Gene: CPEB1 cytoplasmic polyadenylation element binding protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64506.
Further reading
- "Translational control by CPEB: a means to the end". Nat. Rev. Mol. Cell Biol. 2 (7): 521–9. 2001. doi:10.1038/35080081. PMID 11433366.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. 2003. doi:10.1101/gad.1053003. PMID 12629046.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules". J. Cell Sci. 118 (Pt 5): 981–92. 2005. doi:10.1242/jcs.01692. PMID 15731006.
- "Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1". Genes Cells 10 (7): 627–38. 2005. doi:10.1111/j.1365-2443.2005.00870.x. PMID 15966895.
- "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
External links
- Human CPEB1 genome location and CPEB1 gene details page in the UCSC Genome Browser.
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