Biology:CRYZ

Generic protein structure example

Quinone oxidoreductase is an enzyme that in humans is encoded by the CRYZ gene.

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. One pseudogene is known to exist.

External links

• Human CRYZ genome location and CRYZ gene details page in the UCSC Genome Browser.

Further reading

• "Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms". Genomics 23 (2): 403–7. 1995. doi:10.1006/geno.1994.1516. PMID 7835889. 
• "Organization of the human zeta-crystallin/quinone reductase gene (CRYZ)". Genomics 21 (2): 317–24. 1994. doi:10.1006/geno.1994.1272. PMID 8088825. https://zenodo.org/record/1229634. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver". Biochem. Biophys. Res. Commun. 191 (3): 902–7. 1993. doi:10.1006/bbrc.1993.1302. PMID 8466529. https://zenodo.org/record/1229410. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells". Biochem. Pharmacol. 56 (2): 189–95. 1998. doi:10.1016/S0006-2952(98)00141-5. PMID 9698072. 
• "Unfolding and refolding of a quinone oxidoreductase: alpha-crystallin, a molecular chaperone, assists its reactivation". Biochem. J. 359 (Pt 3): 547–56. 2001. doi:10.1042/0264-6021:3590547. PMID 11672428. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. 
• "Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage". Mol. Endocrinol. 17 (7): 1344–55. 2004. doi:10.1210/me.2002-0382. PMID 12714703. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.