Biology:CTNNBIP1

Generic protein structure example

Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.

Function

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. The encoded protein is a negative regulator of the Wnt signaling pathway.

Further reading

• "A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression.". Mol. Cell. Biol. 28 (24): 7368–79. 2008. doi:10.1128/MCB.00744-08. PMID 18852287. 
• "IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli.". J. Biol. Chem. 282 (11): 8545–56. 2007. doi:10.1074/jbc.M610272200. PMID 17255093. 
• "Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors.". BMC Cancer 8: 328. 2008. doi:10.1186/1471-2407-8-328. PMID 18992165. 
• "ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657.". Cell Biochem. Funct. 27 (6): 329–37. 2009. doi:10.1002/cbf.1576. PMID 19569129. 
• "Comparative proteomics analysis on differentiation of human promyelocytic leukemia HL-60 cells into granulocyte and monocyte lineages.". AI Zheng 28 (2): 117–21. 2009. PMID 19550115. 
• "E-cadherin but not beta-catenin expression is decreased in laryngeal biopsies from patients with laryngopharyngeal reflux.". Eur Arch Otorhinolaryngol 265 (8): 937–42. 2008. doi:10.1007/s00405-007-0568-6. PMID 18183411. 
• "Relation between cell-to-cell adhesion and angiogenesis and clinico-morphological prognostic factors in patients with gastric cancer.". Exp. Oncol. 30 (3): 235–9. 2008. PMID 18806748. 
• "Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours.". Hum. Mol. Genet. 18 (2): 213–26. 2009. doi:10.1093/hmg/ddn338. PMID 18854359. 
• "Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin.". Biochem. Biophys. Res. Commun. 357 (1): 81–6. 2007. doi:10.1016/j.bbrc.2007.03.117. PMID 17418091. 
• "MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations.". Hepatology 47 (6): 1955–63. 2008. doi:10.1002/hep.22256. PMID 18433021. http://www.hal.inserm.fr/docs/00/32/95/10/PDF/HEP-07-1716R1.pdf. 
• "Wnt pathway is involved in advanced gastric carcinoma.". Hepatogastroenterology 55 (84): 1126–30. 2008. PMID 18705344. 
• "Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.". Mol. Hum. Reprod. 15 (1): 11–7. 2009. doi:10.1093/molehr/gan070. PMID 19038973. 
• "Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors.". Hum. Pathol. 39 (12): 1802–8. 2008. doi:10.1016/j.humpath.2008.05.005. PMID 18715618. 
• "Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells.". Blood 110 (9): 3334–44. 2007. doi:10.1182/blood-2007-01-068122. PMID 17638851. 
• "Familial medulloblastoma: case report of one family and review of the literature.". Neurosurgery 51 (1): 227–33; discussion 233. 2002. doi:10.1097/00006123-200207000-00035. PMID 12182422. 
• "HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells.". Int. J. Cancer 124 (7): 1526–34. 2009. doi:10.1002/ijc.24072. PMID 19089909. 
• "Amyloid precursor protein modulates beta-catenin degradation.". Journal of Neuroinflammation 4: 29. 2007. doi:10.1186/1742-2094-4-29. PMID 18070361. 
• "Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication.". Int. J. Cancer 124 (1): 103–8. 2009. doi:10.1002/ijc.23917. PMID 18844223. 
• "Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.". Mod. Pathol. 21 (8): 925–36. 2008. doi:10.1038/modpathol.2008.49. PMID 18500270. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931. 

External links

• CTNNBIP1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CTNNBIP1 genome location and CTNNBIP1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.