Biology:CYFIP1
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Cytoplasmic FMR1-interacting protein 1 is a protein that in humans is encoded by the CYFIP1 gene.[1][2]
Interactions
CYFIP1 has been shown to interact with FMR1,[1] to the exclusion of FXR1 and FXR2.[1] It also forms part of the WAVE regulatory complex (WRC),[3] and based on the crystal structure of the WRC it is believed CYFIP1 provides the binding site for the complex to Rac1.[4]
References
- ↑ 1.0 1.1 1.2 "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proc Natl Acad Sci U S A 98 (15): 8844–9. Jul 2001. doi:10.1073/pnas.151231598. PMID 11438699. Bibcode: 2001PNAS...98.8844S.
- ↑ "Entrez Gene: CYFIP1 cytoplasmic FMR1 interacting protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23191.
- ↑ "Structure and control of the actin regulatory WAVE complex". Nature 468 (7323): 533–8. 25 Nov 2010. doi:10.1038/nature09623. PMID 21107423. Bibcode: 2010Natur.468..533C.
- ↑ "WAVE regulatory complex activation by cooperating GTPases Arf and Rac1". Proc Natl Acad Sci U S A 108 (35): 14449–54. 30 Aug 2011. doi:10.1073/pnas.1107666108. PMID 21844371. Bibcode: 2011PNAS..10814449K.
Further reading
- "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. 1995. doi:10.1093/dnares/1.5.223. PMID 7584044.
- "p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.". J. Biol. Chem. 273 (1): 291–5. 1998. doi:10.1074/jbc.273.1.291. PMID 9417078.
- "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.". EMBO J. 17 (4): 967–76. 1998. doi:10.1093/emboj/17.4.967. PMID 9463375.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.". Am. J. Hum. Genet. 73 (4): 898–925. 2003. doi:10.1086/378816. PMID 14508708.
- "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.". J. Biol. Chem. 279 (13): 12804–11. 2004. doi:10.1074/jbc.M312171200. PMID 14676191.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Abi1 is essential for the formation and activation of a WAVE2 signalling complex.". Nat. Cell Biol. 6 (4): 319–27. 2004. doi:10.1038/ncb1105. PMID 15048123.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.". Mol. Cell. Biol. 25 (22): 9920–35. 2005. doi:10.1128/MCB.25.22.9920-9935.2005. PMID 16260607.
- "Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome.". Pediatrics 118 (4): e1276–83. 2006. doi:10.1542/peds.2006-0424. PMID 16982806.
- "Structure and control of the actin regulatory WAVE complex". Nature 468 (7323): 533–8. 25 Nov 2010. doi:10.1038/nature09623. PMID 21107423. Bibcode: 2010Natur.468..533C.
- "WAVE regulatory complex activation by cooperating GTPases Arf and Rac1". Proc Natl Acad Sci U S A 108 (35): 14449–54. 30 Aug 2011. doi:10.1073/pnas.1107666108. PMID 21844371. Bibcode: 2011PNAS..10814449K.
External links
- Human CYFIP1 genome location and CYFIP1 gene details page in the UCSC Genome Browser.
- Human SRA1 genome location and SRA1 gene details page in the UCSC Genome Browser.
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