Biology:Calphostin
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The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.[1][2] The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC).[1][2] The most potent member of the series, calphostin C,[1] has found use as a biochemical tool because of this activity.[3]
| 200px | ||
| Calpohostin | R1 | R2 |
| Calphostin A | Bz | Bz |
| Calphostin B | Bz | H |
| Calphostin C | Bz | 4-(HO)Bz |
| Calphostin D | H | H |
| Calphostin I | 4-(HO)Bz | 4-(HO)Bz |
Calphostin C
Calphostin C is a potent inhibitor of protein kinase C (PKC).[1][2][3]
References
- ↑ 1.0 1.1 1.2 1.3 Kobayashi, E; Ando, K; Nakano, H; Iida, T; Ohno, H; Morimoto, M; Tamaoki, T (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". Journal of Antibiotics 42 (10): 1470–1474. doi:10.7164/antibiotics.42.1470. PMID 2478514.
- ↑ 2.0 2.1 2.2 Iida, T; Kobayashi, E; Yoshida, M; Sano, H (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". Journal of Antibiotics 42 (10): 1475–1481. doi:10.7164/antibiotics.42.1475. PMID 2478515.
- ↑ 3.0 3.1 "Calphostin C". Biomol GmbH. https://www.biomol.com/products/chemicals/biochemicals/calphostin-c-cay15383-100?fs=4064629640.
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