Biology:Caspase recruitment domain-containing protein 8
From HandWiki
Short description: Protein found in humans
 Generic protein structure example |
Caspase recruitment domain-containing protein 8 is a protein that in humans is encoded by the CARD8 gene.[1][2][3]
Function
Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NF-κB) in the context of apoptosis or inflammation, respectively.[3]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. Jul 1999. doi:10.1093/dnares/6.1.63. PMID 10231032.
- ↑ "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer". J Biol Chem 276 (34): 32220–9. Aug 2001. doi:10.1074/jbc.M100433200. PMID 11408476.
- ↑ 3.0 3.1 "Entrez Gene: CARD8 caspase recruitment domain family, member 8". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=22900.
Further reading
- "Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.". J. Immunol. 179 (7): 4867–73. 2007. doi:10.4049/jimmunol.179.7.4867. PMID 17878386.
- "No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample.". Gastroenterology 132 (5): 2080–1. 2007. doi:10.1053/j.gastro.2007.03.087. PMID 17484912.
- "TUCAN (CARD8) genetic variants and inflammatory bowel disease.". Gastroenterology 131 (4): 1190–6. 2006. doi:10.1053/j.gastro.2006.08.008. PMID 17030188.
- "TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells.". BMC Cancer 6. 2006. doi:10.1186/1471-2407-6-166. PMID 16796750.
- "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.". Immunity 20 (3): 319–25. 2004. doi:10.1016/S1074-7613(04)00046-9. PMID 15030775.
- "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.". FEBS Lett. 521 (1–3): 165–9. 2002. doi:10.1016/S0014-5793(02)02869-7. PMID 12067710. Bibcode: 2002FEBSL.521..165S.
- "NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation". Int. J. Oncol. 20 (5): 1035–40. 2002. doi:10.3892/ijo.20.5.1035. PMID 11956601.
- "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis". J. Biol. Chem. 277 (16): 13952–8. 2002. doi:10.1074/jbc.M107811200. PMID 11821383.
- "CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways". J. Biol. Chem. 276 (47): 44069–77. 2001. doi:10.1074/jbc.M107373200. PMID 11551959.
 |  |
