Biology:D-amino acid oxidase activator
| D-amino acid oxidase activator | |
|---|---|
| Identifiers | |
| Symbol | DAOA |
| Alt. symbols | G72, LG72, SG72 |
| NCBI gene | 267012 |
| HGNC | 21191 |
| OMIM | 607408 |
| RefSeq | NM_172370 |
| UniProt | P59103 |
| Other data | |
| Locus | Chr. 13 q33.2 |
D-amino acid oxidase activator (DAOA, also known as G72) is a protein enriched in various parts of brain, spinal cord, and testis. DAOA is thought to interact with D-amino acid oxidase, a peroxisomal enzyme, and its gene was associated with schizophrenia in a number of studies.[1][2] In separate studies it has been shown to confer susceptibility to bipolar disorder. Therefore, it has been important in researching whether the Kraepelinian dichotomy is genuine. The gene itself was discovered during an investigation of chromosomal 13q22-q34 region,[3] which was previously linked to schizophrenia. G72 is transcribed into several proteins due to alternative splicing; the longest protein is called LG72 and consists of 153 amino acids. Although the protein was initially found to interact with DAO in yeast 2-hybrid experiment, one recent in vivo experiment showed LG72 presence only in mitochondria and failed to confirm the interaction.[4]
See also
References
- ↑ "G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis". Biol. Psychiatry 60 (2): 106–14. 2006. doi:10.1016/j.biopsych.2006.01.019. PMID 16581030.
- ↑ Gene Overview of All Published Schizophrenia-Association Studies for DAOA , schizophreniaforum.org
- ↑ "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. 2002. doi:10.1073/pnas.182412499. PMID 12364586. PMC 129739. Bibcode: 2002PNAS...9913675C. https://repub.eur.nl/pub/5910/eur_duijn_121.pdf.
- ↑ "Evidence implicating the candidate schizophrenia/bipolar disorder susceptibility gene G72 in mitochondrial function". Molecular Psychiatry 13 (7): 685–696. 2007. doi:10.1038/sj.mp.4002052. PMID 17684499.
External links
- From schizophrenia research forum website:
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