Biology:D12-methyl RNA motif
From HandWiki
| D12-methyl | |
|---|---|
 Consensus secondary structure and sequence conservation of D12-methyl RNA | |
| Identifiers | |
| Symbol | D12-methyl |
| Rfam | RF02950 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | 0001263 |
| PDB structures | PDBe |
The D12-methyl RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] D12-methyl motifs are found in metagenomic DNA samples, and have not yet been found in a classified organism.
It is ambiguous whether D12-methyl RNAs function as cis-regulatory elements or whether they operate in trans. On the one hand, they are located upstream of protein-coding genes of a variety of types. This fact could suggest that D12-methyl RNAs function in cis. However, many of the associated genes are typical of those located in prophages. Since phage genomes often consist of a small number of large operons, it is possible that the D12-methyl RNAs are simply one of the genetic elements in a long, phage transcriptional unit.
References
- ↑ "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. October 2017. doi:10.1093/nar/gkx699. PMID 28977401.
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