Biology:DAPK2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.[1][2]

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.[2] The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.[3]

References

  1. "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene 18 (23): 3471–80. Jun 1999. doi:10.1038/sj.onc.1202701. PMID 10376525. 
  2. 2.0 2.1 "Entrez Gene: DAPK2 death-associated protein kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23604. 
  3. Shoval, Yishay; Berissi, Hanna; Kimchi, Adi; Pietrokovski, Shmuel (2011). "New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform". PLOS ONE 6 (2): e17344. doi:10.1371/journal.pone.0017344. PMID 21408167. Bibcode2011PLoSO...617344S. 

Further reading