Biology:DAPP1

Generic protein structure example

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.

Further reading

• "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase.". J. Exp. Med. 191 (8): 1319–32. 2000. doi:10.1084/jem.191.8.1319. PMID 10770799. 
• "Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase.". Biochem. J. 349 (Pt 2): 605–10. 2001. doi:10.1042/0264-6021:3490605. PMID 10880360. 
• "Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.". Mol. Cell 6 (2): 373–84. 2000. doi:10.1016/S1097-2765(00)00037-X. PMID 10983984. 
• "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.". Biochem. J. 351 (Pt 1): 19–31. 2001. doi:10.1042/0264-6021:3510019. PMID 11001876. 
• "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. 2001. doi:10.1101/gr.140200. PMID 11042152. 
• "Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines.". J. Biol. Chem. 276 (46): 42767–73. 2001. doi:10.1074/jbc.M107194200. PMID 11524430. 
• "The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival.". J. Exp. Med. 195 (1): 143–9. 2002. doi:10.1084/jem.20011524. PMID 11781373. 
• "TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor.". Mol. Cell. Biol. 22 (15): 5479–91. 2002. doi:10.1128/MCB.22.15.5479-5491.2002. PMID 12101241. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. 
• "Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival.". Immunity 19 (4): 621–32. 2003. doi:10.1016/S1074-7613(03)00275-9. PMID 14563325. 
• "The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism.". J. Biol. Chem. 279 (38): 39775–82. 2004. doi:10.1074/jbc.M403367200. PMID 15247305. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization.". J. Immunol. 173 (9): 5601–9. 2004. doi:10.4049/jimmunol.173.9.5601. PMID 15494510.