Biology:DBC1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.[1][2][3][4][5]
This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.[3]
The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.
References
- ↑ "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet 6 (6): 913–9. Jul 1997. doi:10.1093/hmg/6.6.913. PMID 9175739.
- ↑ "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics 59 (3): 335–8. Nov 1999. doi:10.1006/geno.1999.5891. PMID 10444335.
- ↑ 3.0 3.1 "Entrez Gene: DBC1 deleted in bladder cancer 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1620.
- ↑ "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. June 1997. doi:10.1093/hmg/6.6.913. PMID 9175739.
- ↑ "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics 59 (3): 335–8. August 1999. doi:10.1006/geno.1999.5891. PMID 10444335.
Further reading
- "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III 318 (2): 263–72. 1995. PMID 7757816.
- "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33.". Genomics 48 (3): 277–88. 1998. doi:10.1006/geno.1997.5165. PMID 9545632.
- "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer.". Genes Chromosomes Cancer 26 (2): 171–5. 2000. doi:10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B. PMID 10469456.
- "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1.". Oncogene 20 (23): 2956–64. 2001. doi:10.1038/sj.onc.1204432. PMID 11420708.
- "Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors.". J. Urol. 168 (6): 2645–9. 2002. doi:10.1016/s0022-5347(05)64236-x. PMID 12442002.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "DBCCR1 mediates death in cultured bladder tumor cells.". Oncogene 23 (1): 82–90. 2004. doi:10.1038/sj.onc.1206642. PMID 14712213.
- "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma.". Oncol. Rep. 13 (2): 335–40. 2005. doi:10.3892/or.13.2.335. PMID 15643521.
- "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.". Hum. Mol. Genet. 14 (8): 997–1007. 2005. doi:10.1093/hmg/ddi092. PMID 15746151.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway.". Oncogene 25 (16): 2409–19. 2006. doi:10.1038/sj.onc.1209228. PMID 16369496.
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