Biology:DEC1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.[1][2][3]
Function
The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas, associated with lymph node metastasis, and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas.[3]
References
- ↑ "Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q". Cancer Res 56 (7): 1629–34. May 1996. PMID 8603412.
- ↑ "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32". Genes Chromosomes Cancer 27 (2): 169–76. Feb 2000. doi:10.1002/(SICI)1098-2264(200002)27:2<169::AID-GCC8>3.0.CO;2-M. PMID 10612805.
- ↑ 3.0 3.1 "Entrez Gene: DEC1 deleted in esophageal cancer 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=50514.
Further reading
- "DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence.". J. Biol. Chem. 283 (5): 2896–905. 2008. doi:10.1074/jbc.M708624200. PMID 18025081.
- "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma.". Int. J. Cancer 122 (3): 587–94. 2008. doi:10.1002/ijc.23144. PMID 17943723.
- "The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter.". Oncogene 25 (23): 3296–306. 2006. doi:10.1038/sj.onc.1209363. PMID 16462771.
- "DEC1 expression in 1p-aberrant oligodendroglial neoplasms.". Histol. Histopathol. 20 (4): 1173–7. 2006. PMID 16136500.
- "Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma.". Oncogene 24 (4): 697–705. 2005. doi:10.1038/sj.onc.1208179. PMID 15580306.
- "Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis.". British Journal of Cancer 104 (5): 841–9. Mar 1, 2011. doi:10.1038/bjc.2011.25. PMID 21326238.
- "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma.". International Journal of Cancer 122 (3): 587–94. Feb 1, 2008. doi:10.1002/ijc.23144. PMID 17943723.
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