Biology:DEGS2

Short description: Protein-coding gene in humans

Generic protein structure example

Delta(4)-desaturase, sphingolipid 2 is a protein that in humans is encoded by the DEGS2 gene.

Function

This gene encodes a bifunctional enzyme that is involved in the biosynthesis of sphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase.

Further reading

• "Dihydroceramide-based response to hypoxia". The Journal of Biological Chemistry 286 (44): 38069–38078. Nov 2011. doi:10.1074/jbc.M111.297994. PMID 21914808. 
• "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders 11: 29. 2011. doi:10.1186/1471-2261-11-29. PMID 21658281. 
• "Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation". FEBS Letters 563 (1–3): 93–97. Apr 2004. doi:10.1016/S0014-5793(04)00274-1. PMID 15063729. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.