Biology:DGCR14
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Protein DGCR14 is a protein that in humans is encoded by the DGCR14 gene.[1][2][3]
This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus.[3]
References
- ↑ "A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11". Hum Mol Genet 5 (6): 789–800. Dec 1996. doi:10.1093/hmg/5.6.789. PMID 8776594.
- ↑ "Structural and mutational analysis of a conserved gene (DGSI) from the minimal DiGeorge syndrome critical region". Hum Mol Genet 6 (2): 267–276. Aug 1997. doi:10.1093/hmg/6.2.267. PMID 9063747.
- ↑ 3.0 3.1 "Entrez Gene: DGCR14 DiGeorge syndrome critical region gene 14". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8220.
Further reading
- Rizzu P; Lindsay EA; Taylor C et al. (1996). "Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans". Mamm. Genome 7 (9): 639–643. doi:10.1007/s003359900197. PMID 8703114.
- Lindsay EA; Rizzu P; Antonacci R et al. (1996). "A transcription map in the CATCH22 critical region: identification, mapping, and ordering of four novel transcripts expressed in heart". Genomics 32 (1): 104–112. doi:10.1006/geno.1996.0082. PMID 8786095.
- "Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation". Mamm. Genome 8 (12): 890–895. 1998. doi:10.1007/s003359900606. PMID 9383280.
- Puech A; Saint-Jore B; Funke B et al. (1998). "Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14608–14613. doi:10.1073/pnas.94.26.14608. PMID 9405660.
- "ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene". Hum. Mol. Genet. 7 (4): 629–635. 1998. doi:10.1093/hmg/7.4.629. PMID 9499415.
- "The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein". J. Biol. Chem. 277 (12): 10562–10572. 2002. doi:10.1074/jbc.M110686200. PMID 11751918.
- Tchernev VT; Mansfield TA; Giot L et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMID 11984006.
- Jurica MS; Licklider LJ; Gygi SR et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–439. doi:10.1017/S1355838202021088. PMID 11991638.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Collins JE; Wright CL; Edwards CA et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334.
- Olsen JV; Blagoev B; Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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