Biology:DTNB

Generic protein structure example

Beta dystrobrevin also known as DTNB is a protein which in humans is encoded by the DTNB gene.

Function

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• "Different dystrophin-like complexes are expressed in neurons and glia.". J. Cell Biol. 147 (3): 645–58. 1999. doi:10.1083/jcb.147.3.645. PMID 10545507. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. 
• "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174. 
• "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells.". J. Biol. Chem. 275 (21): 15851–60. 2000. doi:10.1074/jbc.M000439200. PMID 10747910. 
• "Identification and characterization of a novel member of the dystrobrevin gene family.". FEBS Lett. 425 (1): 7–13. 1998. doi:10.1016/S0014-5793(98)00097-0. PMID 9540997. 
• "Beta-dystrobrevin interacts directly with kinesin heavy chain in brain.". J. Cell Sci. 116 (Pt 23): 4847–56. 2003. doi:10.1242/jcs.00805. PMID 14600269. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Muscular dystrophies and the dystrophin-glycoprotein complex.". Curr. Opin. Neurol. 10 (2): 168–75. 1997. doi:10.1097/00019052-199704000-00016. PMID 9146999. 
• "Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein.". Biochem. J. 395 (3): 587–98. 2006. doi:10.1042/BJ20051965. PMID 16448387. 
• "Many sequence variants affecting diversity of adult human height.". Nat. Genet. 40 (5): 609–15. 2008. doi:10.1038/ng.122. PMID 18391951. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes.". J. Biol. Chem. 279 (8): 7014–23. 2004. doi:10.1074/jbc.M312205200. PMID 14623885. 
• "beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations.". J. Biol. Chem. 272 (50): 31561–9. 1997. doi:10.1074/jbc.272.50.31561. PMID 9395493. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. 
• "Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain.". J. Biol. Chem. 276 (26): 24232–41. 2001. doi:10.1074/jbc.M010418200. PMID 11316798. 
• "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. 2004. doi:10.1186/gb-2004-5-2-r8. PMID 14759258. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.