Biology:DUSP12
 Generic protein structure example |
Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.[1][2]
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.[2]
References
- ↑ "Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function". J Biol Chem 274 (34): 23991–5. Sep 1999. doi:10.1074/jbc.274.34.23991. PMID 10446167.
- ↑ 2.0 2.1 "Entrez Gene: DUSP12 dual specificity phosphatase 12". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11266.
Further reading
- "Type 2 diabetes susceptibility genes on chromosome 1q21-24.". Ann. Hum. Genet. 72 (Pt 2): 163–9. 2008. doi:10.1111/j.1469-1809.2007.00416.x. PMID 18269685.
- "Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.". Diabetes 55 (9): 2631–9. 2006. doi:10.2337/db05-1369. PMID 16936214.
- "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.". EMBO J. 15 (14): 3621–32. 1996. doi:10.1002/j.1460-2075.1996.tb00731.x. PMID 8670865.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9UNI6 (Dual specificity protein phosphatase 12) at the PDBe-KB.
 |  |
