Biology:Daf-4
From HandWiki
| abnormal dauer formation protein 4 | |||||||
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| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-4 | ||||||
| Entrez | 175781 | ||||||
| HomoloGene | 124563 | ||||||
| UniProt | P50488 | ||||||
| Other data | |||||||
| Chromosome | III: 5.63 - 5.63 Mb | ||||||
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The DAF-4 gene encodes for the only type II receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans,[1] with the ligands Daf-7 or Dbl-1.[2] When binds to the ligand Daf-7, Daf-4 complexed with the type I receptor Daf-1, and activated the Smad Protein Daf-8/14. By contrast, when binds to Dbl-1, Daf-4 complexed with the Sma-6 type I receptor, and activated the Sma-2/3/4.[3]
References
- ↑ "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling". Proceedings of the National Academy of Sciences of the United States of America 98 (11): 6284–8. May 2001. doi:10.1073/pnas.111409798. PMID 11353865. Bibcode: 2001PNAS...98.6284M.
- ↑ "Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components". Proceedings of the National Academy of Sciences of the United States of America 93 (2): 790–4. January 1996. doi:10.1073/pnas.93.2.790. PMID 8570636. Bibcode: 1996PNAS...93..790S.
- ↑ "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". Development 126 (2): 251–60. January 1999. doi:10.1242/dev.126.2.251. PMID 9847239.
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