Biology:TGF-beta receptor family
| Ser/Thr protein kinase, TGFB receptor | |
|---|---|
| Identifiers | |
| Symbol | TGFb_receptor |
| InterPro | IPR000333 |
| SCOP2 | 1B6C / SCOPe / SUPFAM |
| Membranome | 1216 |
The transforming growth factor beta (TGFβ) receptors are a family of serine/threonine kinase receptors involved in TGF beta signaling pathway. These receptors bind growth factor and cytokine signaling proteins in the TGF-beta family such as TGFβs (TGFβ1, TGFβ2, TGFβ3), bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activin and inhibin, myostatin, anti-Müllerian hormone (AMH), and NODAL.[1]
TGFβ family receptors
TGFβ family receptors are grouped into three types, type I, type II, and type III. There are seven type I receptors, termed the activin-like receptors (ALK1–7), five type II receptors, and one type III receptor, for a total of 13 TGFβ superfamily receptors.[2][3] In the transduction pathway, ligand-bound type II receptors activate type I receptors by phosphorylation, which then autophosphorylate and bind SMAD.[4] The Type I receptors have a glycine-serine (GS, or TTSGSGSG) repeat motif of around 30 AA, a target of type II activity. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.[5]
Type I
| Transforming growth factor beta type I GS-motif | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TGF_beta_GS | ||||||||
| Pfam | PF08515 | ||||||||
| InterPro | IPR003605 | ||||||||
| |||||||||
- ALK1 (ACVRL1)
- ALK2 (ACVR1A)
- ALK3 (BMPR1A)
- ALK4 (ACVR1B)
- ALK5 (TGFβR1)
- ALK6 (BMPR1B)
- ALK7 (ACVR1C)
Type II
Type III
Unlike the Type I and II receptors which are kinases, TGFBR3 has a Zona pellucida-like domain. Its core domain binds TGF-beta family ligands and its heparan sulfate chains bind bFGF. It acts as a reservoir of ligand for TGF-beta receptors.[6][7]
- TGFβR3 (β-glycan)
References
- ↑ "Prosite Documentation PDOC00223". http://www.expasy.org/cgi-bin/nicedoc.pl?PS00250.
- ↑ Fliesler, Steven J.; Kisselev, Oleg G. (26 December 2007). Signal Transduction in the Retina. CRC Press. pp. 273–. ISBN 978-1-4200-0716-9. https://books.google.com/books?id=frEQu0Hc6scC&pg=PA273.
- ↑ Thiriet, Marc (14 December 2011). Signaling at the Cell Surface in the Circulatory and Ventilatory Systems. Springer Science & Business Media. pp. 666–. ISBN 978-1-4614-1991-4. https://books.google.com/books?id=MF_kmIWZRrMC&pg=PA666.
- ↑ "TGF beta signals through a heteromeric protein kinase receptor complex". Cell 71 (6): 1003–14. December 1992. doi:10.1016/0092-8674(92)90395-S. PMID 1333888.
- ↑ Huse, M; Muir, TW; Xu, L; Chen, YG; Kuriyan, J; Massagué, J (September 2001). "The TGF beta receptor activation process: an inhibitor- to substrate-binding switch.". Molecular Cell 8 (3): 671–82. doi:10.1016/S1097-2765(01)00332-X. PMID 11583628.
- ↑ "Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta". J. Cell Biol. 109 (6 (Pt 1)): 3137–3145. 1989. doi:10.1083/jcb.109.6.3137. PMID 2592419.
- ↑ "Binding of two growth factor families to separate domains of the proteoglycan betaglycan". J. Biol. Chem. 267 (9): 5927–5930. 1992. doi:10.1016/S0021-9258(18)42643-9. PMID 1556106.
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