Biology:Delta catenin

From HandWiki
catenin (cadherin-associated protein), delta 1
Identifiers
SymbolCTNND1
Alt. symbolsCTNND
NCBI gene1500
HGNC2515
OMIM601045
RefSeqNM_001331
UniProtO60716
Other data
LocusChr. 11 q12.1
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Identifiers
SymbolCTNND2
NCBI gene1501
HGNC2516
OMIM604275
RefSeqNM_001332
UniProtQ9UQB3
Other data
LocusChr. 5 p15.2

Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.[1] Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins.[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.[3]

While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin 1 has been implicated as a regulator of the NF-κB transcription factor.[4]

Palmitoylation of delta-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.[5]

References

  1. "Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction". Curr. Biol. 14 (18): 1657–63. September 2004. doi:10.1016/j.cub.2004.08.065. PMID 15380068. 
  2. "Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1". Mol. Cell. Neurosci. 30 (4): 611–23. December 2005. doi:10.1016/j.mcn.2005.06.005. PMID 16456928. 
  3. "Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation". Proc. Natl. Acad. Sci. U.S.A. 102 (34): 12171–6. August 2005. doi:10.1073/pnas.0504600102. PMID 16093313. 
  4. "p120-catenin mediates inflammatory responses in the skin". Cell 124 (3): 631–44. February 2006. doi:10.1016/j.cell.2005.11.043. PMID 16469707. 
  5. "Palmitoylation of [delta-catenin by DHHC5 mediates activity-induced synapse plasticity"]. Nature Neuroscience 17 (4): 522–532. January 23, 2014. doi:10.1038/nn.3657. PMID 24562000. 

See also