Biology:Dichroa febrifuga

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Short description: Species of plant

Dichroa febrifuga
Dichroa febrifuga Glasgow.jpg
Scientific classification edit
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Cornales
Family: Hydrangeaceae
Genus: Dichroa
Species:
D. febrifuga
Binomial name
Dichroa febrifuga
Lour.[1]
A white flowering variety

Dichroa febrifuga is a flowering plant in the family Hydrangeaceae.

National names

  • Chinese: Chinese: 常山; pinyin: About this soundchángshān (help·info))
  • Indonesian language: gigil, alternatively tataruman
  • Sundanese: ramram
  • Papua: Hom dong (ฮอมดง):
  • Thai: Yai khlang yai (ยายคลังใหญ่), in Nakhon Sri Thammarat, Yai Krang (ยายกรัง) in the South, and Hom Kham (ฮอมคำ) in Lanna (Northern Thai).

Traditional Chinese medicine

Dichroa febrifuga is an important herb in traditional Chinese medicine, where it is considered one of the 50 fundamental herbs.[2] The alkaloids febrifugine and isofebrifugine are believed to be responsible for its antimalarial effects.[3] In traditional preparations, it is used in conjunction with other plants such as Glycyrrhiza glabra (licorice), Ziziphus jujuba and Zingiber officinale (ginger).[4]

Potential drug against autoimmune disease

Halofuginone, sold under the brand name Halocur, is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in dichroa febrifuga.[5]

Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.[6] Halofuginone therefore has potential for the treatment of autoimmune disorders.[7]

References

  1. ↑ {{citation | mode = cs1 | title = Dichroa febrifuga | work = Germplasm Resources Information Network (GRIN) | url = | publisher = [[Organization:Agricultural Research ServAgricultural Research Service (ARS), United States Department of Agriculture (USDA) | access-date = 2008-02-05 }}
  2. ↑ "Dichroa febrifuga - Plants For A Future database report". http://www.pfaf.org/database/plants.php?Dichroa+febrifuga. 
  3. ↑ Zhu, Shuren; Meng, Li; Zhang, Quan; Wei, Lai (2006). "Synthesis and evaluation of febrifugine analogues as potential antimalarial agents". Bioorganic & Medicinal Chemistry Letters 16 (7): 1854–1858. doi:10.1016/j.bmcl.2006.01.009. PMID 16434194. 
  4. ↑ Rasoanaivo, Philippe; Wright, Colin W; Willcox, Merlin L; Gilbert, Ben (2011). "Whole plant extracts versus single compounds for the treatment of malaria: Synergy and positive interactions". Malaria Journal 10 (Suppl 1): S4. doi:10.1186/1475-2875-10-S1-S4. PMID 21411015. 
  5. ↑ "Halofuginone hydrobromide". NCI Drug Dictionary. National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services. http://www.cancer.gov/drugdictionary/?CdrID=38485. 
  6. ↑ "Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response". Science 324 (5932): 1334–8. June 2009. doi:10.1126/science.1172638. PMID 19498172. Bibcode: 2009Sci...324.1334S. 
  7. ↑ "Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response". Science 324 (5932): 1334–8. June 2009. doi:10.1126/science.1172638. PMID 19498172. Bibcode: 2009Sci...324.1334S. 
    • "A new lead for autoimmune disease". EurekAlert! (Press release). 4 June 2009.

External links

Wikidata ☰ Q1100840 entry




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