Biology:EEF1B2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Elongation factor 1-beta is a protein that in humans is encoded by the EEF1B2 gene.[1][2]
Function
This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR.[2]
Interactions
EEF1B2 has been shown to interact with EEF1G[3][4] and HARS.[5]
References
- ↑ "Human elongation factor EF-1 beta: cloning and characterization of the EF1 beta 5a gene and assignment of EF-1 beta isoforms to chromosomes 2,5,15 and X". Biochemical and Biophysical Research Communications 197 (1): 154–62. Nov 1993. doi:10.1006/bbrc.1993.2454. PMID 8250921.
- ↑ 2.0 2.1 "Entrez Gene: EEF1B2 eukaryotic translation elongation factor 1 beta 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1933.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- ↑ "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications 291 (1): 158–64. Feb 2002. doi:10.1006/bbrc.2002.6398. PMID 11829477.
Further reading
- "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis 13 (12): 960–9. Dec 1992. doi:10.1002/elps.11501301199. PMID 1286667.
- "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis 13 (12): 992–1001. Dec 1992. doi:10.1002/elps.11501301201. PMID 1286669.
- "Human elongation factor 1 beta: cDNA and derived amino acid sequence". Biochemical and Biophysical Research Communications 177 (1): 312–7. May 1991. doi:10.1016/0006-291X(91)91984-K. PMID 1710449.
- "Nucleotide sequence of human elongation factor-1 beta cDNA". Nucleic Acids Research 19 (16): 4551. Aug 1991. doi:10.1093/nar/19.16.4551. PMID 1886777.
- "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry 264 (35): 21131–7. Dec 1989. doi:10.1016/S0021-9258(19)30056-0. PMID 2556394.
- "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters 238 (2): 262–4. Oct 1988. doi:10.1016/0014-5793(88)80492-7. PMID 3169261.
- "Expression of recombinant elongation factor 1 beta from rabbit in Escherichia coli. Phosphorylation by casein kinase II". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1264 (3): 303–11. Dec 1995. doi:10.1016/0167-4781(95)00166-2. PMID 8547318.
- "Human lymphocyte cDNA ordered library analyzed by 2D gel electrophoresis. 3. Analysis of individual clones". Applied and Theoretical Electrophoresis 5 (2): 99–105. 1996. PMID 8573604.
- "Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum". Journal of Cell Science 109 ( Pt 5) (5): 1113–7. May 1996. doi:10.1242/jcs.109.5.1113. PMID 8743958. https://biblio.ugent.be/publication/01GJAXGWEXX2G4TPB1AKB720BQ.
- "Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". The Journal of Biological Chemistry 272 (52): 33290–7. Dec 1997. doi:10.1074/jbc.272.52.33290. PMID 9407120.
- "A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII". Molecular and Cellular Biochemistry 191 (1–2): 181–6. Jan 1999. doi:10.1023/A:1006802125856. PMID 10094407.
- "The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking resemblance to that of EF-Ts from Escherichia coli". Structure 7 (2): 217–26. Feb 1999. doi:10.1016/S0969-2126(99)80027-6. PMID 10368288.
- "Comparative genomic analysis of genes encoding translation elongation factor 1B(alpha) in human and mouse shows EEF1B1 to be a recent retrotransposition event". Genomics 77 (3): 145–8. Oct 2001. doi:10.1006/geno.2001.6626. PMID 11597139.
- "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications 291 (1): 158–64. Feb 2002. doi:10.1006/bbrc.2002.6398. PMID 11829477.
- "Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A". Proceedings of the National Academy of Sciences of the United States of America 100 (24): 13892–7. Nov 2003. doi:10.1073/pnas.2335950100. PMID 14623968. Bibcode: 2003PNAS..10013892C.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. Aug 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B". Structure 12 (9): 1693–704. Sep 2004. doi:10.1016/j.str.2004.07.010. PMID 15341733.
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