Biology:EIF3K
From HandWiki
Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene.[1][2][3]
Function
The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 43S preinitiation complex.[4][3]
Interactions
eIF3k has been shown to interact with Cyclin D3[5] and eIF3a.[2][6]
See also
References
- ↑ "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research 10 (10): 1546–60. October 2000. doi:10.1101/gr.140200. PMID 11042152.
- ↑ 2.0 2.1 "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". European Journal of Biochemistry 270 (20): 4133–9. October 2003. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
- ↑ 3.0 3.1 "Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=27335.
- ↑ "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". European Journal of Biochemistry 270 (20): 4133–9. 2003. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
- ↑ "Identification of the p28 subunit of eukaryotic initiation factor 3 (eIF3k) as a new interaction partner of cyclin D3". FEBS Letters 573 (1–3): 139–46. August 2004. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1). 2007. doi:10.1038/msb4100134. PMID 17353931.
Further reading
- "PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact". Molecular Biology of the Cell 13 (5): 1722–34. May 2002. doi:10.1091/mbc.02-02-0011. PMID 12006665.
- "Crystal structure of human eIF3k, the first structure of eIF3 subunits". The Journal of Biological Chemistry 279 (33): 34983–90. August 2004. doi:10.1074/jbc.M405158200. PMID 15180986.
- "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Letters 573 (1–3): 139–46. August 2004. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9UBQ5 (Human Eukaryotic translation initiation factor 3 subunit K (EIF3K)) at the PDBe-KB.
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