Biology:EIF5

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.

EIF5 is a GTPase-activating protein.

External links

• Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)

Further reading

• "Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2.". J. Biol. Chem. 272 (50): 31712–8. 1998. doi:10.1074/jbc.272.50.31712. PMID 9395514. 
• "Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells.". Nucleic Acids Res. 27 (5): 1331–7. 1999. doi:10.1093/nar/27.5.1331. PMID 9973622. 
• "Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo.". Mol. Cell. Biol. 20 (11): 3942–50. 2000. doi:10.1128/MCB.20.11.3942-3950.2000. PMID 10805737. 
• "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2.". Mol. Cell. Biol. 20 (19): 7183–91. 2000. doi:10.1128/MCB.20.19.7183-7191.2000. PMID 10982835. 
• "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.". J. Biol. Chem. 276 (9): 6720–6. 2001. doi:10.1074/jbc.M008863200. PMID 11092890. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.". EMBO J. 20 (9): 2326–37. 2001. doi:10.1093/emboj/20.9.2326. PMID 11331597. 
• "Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo.". Nucleic Acids Res. 30 (5): 1154–62. 2002. doi:10.1093/nar/30.5.1154. PMID 11861906. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. 2003. doi:10.1073/pnas.0437845100. PMID 12569173. Bibcode: 2003PNAS..100.1535M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression.". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15688–93. 2005. doi:10.1073/pnas.0506791102. PMID 16227438. Bibcode: 2005PNAS..10215688H. 
• "Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors.". Biochemistry 45 (14): 4550–8. 2006. doi:10.1021/bi052387u. PMID 16584190. 
• "The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5.". J. Mol. Biol. 360 (2): 457–65. 2006. doi:10.1016/j.jmb.2006.05.021. PMID 16781736. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.