Biology:EIF5B
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.[1][2][3]
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in bacteria which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.[3]
References
- ↑ "Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2". Proc Natl Acad Sci U S A 96 (8): 4342–7. May 1999. doi:10.1073/pnas.96.8.4342. PMID 10200264. Bibcode: 1999PNAS...96.4342L.
- ↑ "Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix". Biochem J. 342 ( Pt 1) (Pt 1): 97–103. Oct 1999. doi:10.1042/bj3420097. PMID 10432305.
- ↑ 3.0 3.1 "Entrez Gene: EIF5B eukaryotic translation initiation factor 5B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9669.
Further reading
- "Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probing.". EMBO J. 26 (13): 3109–23. 2007. doi:10.1038/sj.emboj.7601751. PMID 17568775.
- "Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene.". Mitochondrion 7 (3): 195–203. 2007. doi:10.1016/j.mito.2006.10.005. PMID 17161026.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.". Proteomics 5 (14): 3589–99. 2006. doi:10.1002/pmic.200401217. PMID 16097034.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. 2003. doi:10.1073/pnas.0437845100. PMID 12569173. Bibcode: 2003PNAS..100.1535M.
- "Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo.". EMBO J. 22 (2): 193–204. 2003. doi:10.1093/emboj/cdg030. PMID 12514125.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers.". IUBMB Life 51 (5): 321–7. 2002. doi:10.1080/152165401317190842. PMID 11699879.
- "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. 1999. doi:10.1093/dnares/5.5.277. PMID 9872452.
 |  |
