Biology:Ectopic hormone
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Short description: Ectopic hormone: Definition of medical term
An ectopic hormone is a hormone produced by tumors derived from tissue that is not typically associated with its production.[1]
On the other hand, the term entopic is used to refer to hormones produced by tissue in tumors that are normally engaged in the production of that hormone. [2]
The excess hormone secretion is considered detrimental to the normal body homeostasis.[3] This hormone production typically results in a set of signs and symptoms that are called a paraneoplastic syndrome.[2]
Some clinical syndromes caused by ectopic hormone production include:
| Syndrome | Main causal cancers | Ectopic hormone | |
|---|---|---|---|
| Cushing syndrome | Ectopic ACTH and ACTH-like substance | ||
| Syndrome of inappropriate antidiuretic hormone |
|
Ectopic Antidiuretic hormone[4] | |
| Hypercalcemia |
|
Ectopic PTHrP (Parathyroid hormone-related protein), TGF-α, TNF, IL-1[4] | |
| Hypoglycemia | Ectopic Insulin-like growth factor 2 | ||
| Hyperaldosteronism |
|
Ectopic Aldosterone[6] |
References
- ↑ 1.0 1.1 "Endocrine Paraneoplastic Syndromes ("Ectopic" Hormone Production)". https://www.ncbi.nlm.nih.gov/books/NBK12609/.
- ↑ 2.0 2.1 Ectopic Hormone Syndromes. Oxford University Press. ISBN 978-0-19-960823-2. https://oxfordmedicine.com/view/10.1093/med/9780199235292.001.1/med-9780199235292-chapter-110102. Retrieved 28 February 2022.
- ↑ "Ectopic hormones". https://www.nature.com/subjects/ectopic-hormones.
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 Table 6-5 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). Robbins Basic Pathology. Philadelphia: Saunders. ISBN 978-1-4160-2973-1. 8th edition.
- ↑ 5.0 5.1 "Cancer-Related Hypercalcemia". J Oncol Pract 12 (5): 426–32. 2016. doi:10.1200/JOP.2016.011155. PMID 27170690.
- ↑ "Paraneoplastic hyperaldosteronism associated with non-Hodgkin's lymphoma". New England Journal of Medicine 344 (20): 1558–9. May 2001. doi:10.1056/NEJM200105173442017. PMID 11368052.
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