Biology:Electrogenic sodium bicarbonate cotransporter 1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a membrane transport protein that in humans is encoded by the SLC4A4 gene.[1][2][3]

Function

Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate co-transport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM][3]

Clinical significance

In the brain, the sodium bicarbonate transporter is predominantly expressed by astrocytes.[4] They may participate in regulation of brain extracellular space pH.[5] Some mutations in the gene have been associated with familial hemiplegic migraine.[6] Other mutations disrupt kidney bicarbonate transport and cause proximal renal tubular acidosis.[7]

Splice variants

NBCe1-A aka kNBC1 (mainly expressed in the kidney)

NBCe1-B aka pNBC1 (expressed in the pancreas and elsewhere)

NBCe1-C (expressed in the brain)

Distribution

The renal SLC4A4 gene product NBCe1-A is specifically expressed in the basolateral membranes of proximal tubule epithelia.

See also

References

  1. ↑ "Cloning and functional expression of a human kidney Na+:HCO3- cotransporter". J Biol Chem 272 (31): 19111–4. Aug 1997. doi:10.1074/jbc.272.31.19111. PMID 9235899. 
  2. ↑ "Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter". J Biol Chem 273 (28): 17689–95. Aug 1998. doi:10.1074/jbc.273.28.17689. PMID 9651366. 
  3. ↑ 3.0 3.1 "Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8671. 
  4. ↑ Theparambil, Shefeeq M.; Hosford, Patrick S.; Ruminot, Iván; Kopach, Olga; Reynolds, James R.; Sandoval, Pamela Y.; Rusakov, Dmitri A.; Barros, L. Felipe et al. (2020-10-08). "Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle" (in en). Nature Communications 11 (1): 5073. doi:10.1038/s41467-020-18756-3. ISSN 2041-1723. PMID 33033238. Bibcode: 2020NatCo..11.5073T. 
  5. ↑ Theparambil, Shefeeq M.; Hosford, Patrick S.; Ruminot, Iván; Kopach, Olga; Reynolds, James R.; Sandoval, Pamela Y.; Rusakov, Dmitri A.; Barros, L. Felipe et al. (2020-10-08). "Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle" (in en). Nature Communications 11 (1): 5073. doi:10.1038/s41467-020-18756-3. ISSN 2041-1723. PMID 33033238. Bibcode: 2020NatCo..11.5073T. 
  6. ↑ "Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine". Proc. Natl. Acad. Sci. U.S.A. 107 (36): 15963–8. September 2010. doi:10.1073/pnas.1008705107. PMID 20798035. 
  7. ↑ "Topological location and structural importance of the NBCe1-A residues mutated in proximal renal tubular acidosis". J. Biol. Chem. 285 (18): 13416–26. April 2010. doi:10.1074/jbc.M109.093286. PMID 20197274. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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