Biology:Endothelin converting enzyme 1

Generic protein structure example

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.

Function

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.

Further reading

• "Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2". Biochem. Biophys. Res. Commun. 208 (2): 721–7. 1995. doi:10.1006/bbrc.1995.1397. PMID 7695628. 
• "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Lett. 356 (2–3): 238–43. 1995. doi:10.1016/0014-5793(94)01277-6. PMID 7805846. 
• "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochem. Biophys. Res. Commun. 207 (2): 807–12. 1995. doi:10.1006/bbrc.1995.1258. PMID 7864876. 
• "Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)". J. Biol. Chem. 270 (50): 29794–8. 1996. doi:10.1074/jbc.270.50.29794. PMID 8530372. 
• "Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1". Cytogenet. Cell Genet. 72 (4): 322–4. 1996. doi:10.1159/000134214. PMID 8641140. 
• "Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells". J. Mol. Med. 75 (7): 512–21. 1997. doi:10.1007/s001090050136. PMID 9253714. 
• "Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations". Biochem. J. 328 (Pt 3): 871–7. 1998. doi:10.1042/bj3280871. PMID 9396733. 
• "The processing pathway of endothelin-1 production". J. Cardiovasc. Pharmacol. 31 Suppl 1: S13–5. 1998. doi:10.1097/00005344-199800001-00006. PMID 9595387. 
• "A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction". Am. J. Hum. Genet. 64 (1): 304–8. 1999. doi:10.1086/302184. PMID 9915973. 
• "Proteolytic processing of big endothelin-3 by the kell blood group protein". Blood 94 (4): 1440–50. 1999. doi:10.1182/blood.V94.4.1440. PMID 10438732. 
• "A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization". Eur. J. Biochem. 264 (2): 341–9. 1999. doi:10.1046/j.1432-1327.1999.00602.x. PMID 10491078. 
• "Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells". Arch. Biochem. Biophys. 373 (2): 385–93. 2000. doi:10.1006/abbi.1999.1586. PMID 10620363. 
• "Superoxide regulation of endothelin-converting enzyme". J. Biol. Chem. 275 (34): 26423–7. 2000. doi:10.1074/jbc.M000767200. PMID 10833511. 
• "Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis". J. Biol. Chem. 277 (7): 5395–403. 2002. doi:10.1074/jbc.M105874200. PMID 11723113. 
• "Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP)". J. Med. Chem. 45 (7): 1477–86. 2002. doi:10.1021/jm0005454. PMID 11906289. 
• "Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms". J. Biol. Chem. 277 (48): 46355–63. 2003. doi:10.1074/jbc.M207972200. PMID 12244060. 
• "Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease". J. Biol. Chem. 278 (1): 545–55. 2003. doi:10.1074/jbc.M208949200. PMID 12393864. 
• "Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme". J. Biol. Chem. 278 (4): 2081–4. 2003. doi:10.1074/jbc.C200642200. PMID 12464614. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress". Regul. Pept. 111 (1–3): 13–9. 2003. doi:10.1016/S0167-0115(02)00219-7. PMID 12609744. 
• "On the role of endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer". Breast Cancer Res. Treat. 106 (3): 361–9. 2007. doi:10.1007/s10549-007-9516-9. PMID 17295044.