Biology:Endozepine
From HandWiki
Endozepines are endogenous compounds with benzodiazepine like effects. They have been linked to hepatic encephalopathy and have controversially been linked to some cases of recurrent stupor.[1] Initially, the key diagnostic test is stupor which is sensitive to the benzodiazepine receptor antagonist flumazenil in the absences of exogenous benzodiazepines. Potential candidates for these compounds are:[2]
- oleamides
- nonpeptidic endozepines such as inosine
- the protein Diazepam binding inhibitor (DBI)
References
- ↑ Cortelli, P.; Avallone, R.; Baraldi, M.; Zeneroli, ML.; Mandrioli, J.; Corsi, L.; Riva, R.; Tinuper, P. et al. (Dec 2005). "Endozepines in recurrent stupor". Sleep Med Rev 9 (6): 477–87. doi:10.1016/j.smrv.2005.07.003. PMID 16233983.
- ↑ Farzampour, Z; Reimer, RJ; Huguenard, J (2015). "Endozepines". Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A. Advances in Pharmacology (San Diego, Calif.). 72. pp. 147–64. doi:10.1016/bs.apha.2014.10.005. ISBN 9780128026601.
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