Biology:Epstein–Barr virus small nucleolar RNA 1
| Human herpesvirus 1 small nucleolar RNA | |
|---|---|
 Sequence concservation of v-snoRNA1 | |
| Identifiers | |
| Symbol | v-snoRNA1 |
| Rfam | RF01516 |
| Other data | |
| RNA type | snoRNA |
| PDB structures | PDBe |
V-snoRNA1 is a box CD-snoRNA[clarification needed] identified in B lymphocytes infected with the Epstein–Barr virus (human herpesvirus 4 (HHV-4)).[1] This snoRNA is the first known example of a snoRNA expressed from a viral genome.[2] It is homologous to eukaryotic snoRNAs because it contains the C and D boxes sequence motifs[clarification needed] but lacks a terminal stem-loop structure. The nucleolar localization of v-snoRNA1 was determined by in situ hybridization. V-snoRNA1 can form into a ribonucleoprotein complex (snoRNP) as co-immunoprecipitation (CoIP) assays showed that this snoRNA interacts with the snoRNA core proteins, fibrillarin, Nop56, Nop58.[clarification needed] It has also been proposed that this snoRNA may act as a miRNA-like precursor that is processed into 24-nucleotide-sized RNA fragments that target the 3'UTR[clarification needed] of viral DNA polymerase mRNA.[1]
See also
- Epstein–Barr virus stable intronic sequence RNAs
References
- ↑ 1.0 1.1 Cullen, Bryan R, ed (August 2009). "Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome". PLOS Pathogens 5 (8): e1000547. doi:10.1371/journal.ppat.1000547. PMID 19680535.
- ↑ "SnoPatrol: how many snoRNA genes are there?". Journal of Biology 9 (1): 4. 2010. doi:10.1186/jbiol211. PMID 20122292.
External links
- Page for human herpesvirus 1 small nucleolar RNA at Rfam
- Page for EBER1 at Rfam
- Page for v-snoRNA1 at Rfam
- Page for IRES EBNA at Rfam
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