Biology:FABP5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene.[1][2]
Function
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.[2]
The phytocannabinoids (THC and CBD) inhibit endocannabinoid anandamide (AEA) uptake by targeting FABP5, and competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids.[3] Results show that cannabinoids inhibit keratinocyte proliferation, and therefore support a potential role for cannabinoids in the treatment of psoriasis.[4]
Interactions
FABP5 has been shown to interact with S100A7.[5][6]
References
- ↑ "Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins". The Journal of Investigative Dermatology 99 (3): 299–305. September 1992. doi:10.1111/1523-1747.ep12616641. PMID 1512466.
- ↑ 2.0 2.1 "Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2171.
- ↑ "Fatty acid-binding proteins (FABPs) are intracellular carriers for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD)". The Journal of Biological Chemistry 290 (14): 8711–21. April 2015. doi:10.1074/jbc.M114.618447. PMID 25666611.
- ↑ "Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis" (in en). Journal of Dermatological Science 45 (2): 87–92. February 2007. doi:10.1016/j.jdermsci.2006.10.009. PMID 17157480. https://www.jdsjournal.com/article/S0923-1811(06)00315-X/fulltext.
- ↑ "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". The Journal of Investigative Dermatology 121 (1): 132–41. July 2003. doi:10.1046/j.1523-1747.2003.12309.x. PMID 12839573.
- ↑ "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Molecular and Cellular Biochemistry 192 (1–2): 123–8. February 1999. doi:10.1023/A:1006894909694. PMID 10331666.
Further reading
- "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis 13 (12): 960–9. December 1992. doi:10.1002/elps.11501301199. PMID 1286667.
- "Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro". The Biochemical Journal 302 ( Pt 2) (2): 363–71. September 1994. doi:10.1042/bj3020363. PMID 8092987.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP)". Biochemical and Biophysical Research Communications 190 (2): 482–7. January 1993. doi:10.1006/bbrc.1993.1073. PMID 8427590.
- "Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study". Dermatology 192 (3): 208–13. 1996. doi:10.1159/000246367. PMID 8726632.
- "LP2, a differentiation-associated lipid-binding protein expressed in bovine lens". The Biochemical Journal 320 ( Pt 1) (1): 49–54. November 1996. doi:10.1042/bj3200049. PMID 8947466.
- "Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein". Circulation Research 81 (3): 297–303. September 1997. doi:10.1161/01.res.81.3.297. PMID 9285630.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin". Journal of Dermatological Science 16 (1): 17–22. November 1997. doi:10.1016/S0923-1811(97)00615-4. PMID 9438903.
- "Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes". The Biochemical Journal 339 ( Pt 2) (2): 419–27. April 1999. doi:10.1042/0264-6021:3390419. PMID 10191275.
- "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Molecular and Cellular Biochemistry 192 (1–2): 123–8. February 1999. doi:10.1023/A:1006894909694. PMID 10331666.
- "Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein". Biochemistry 38 (38): 12229–39. September 1999. doi:10.1021/bi990305u. PMID 10493790.
- "PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation". FEBS Letters 486 (2): 149–54. December 2000. doi:10.1016/S0014-5793(00)02252-3. PMID 11113456.
- "Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP)". The Biochemical Journal 364 (Pt 3): 725–37. June 2002. doi:10.1042/BJ20020039. PMID 12049637.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. May 2003. doi:10.1038/nbt810. PMID 12665801.
- "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". The Journal of Investigative Dermatology 121 (1): 132–41. July 2003. doi:10.1046/j.1523-1747.2003.12309.x. PMID 12839573.
- "Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells". Experimental Dermatology 13 (9): 543–50. September 2004. doi:10.1111/j.0906-6705.2004.00196.x. PMID 15335354.
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