Biology:FBXL7
 Generic protein structure example |
F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.[1][2][3]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.
The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.[3]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. May 1999. doi:10.1093/dnares/5.6.355. PMID 10048485.
- ↑ "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. Dec 1999. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
- ↑ 3.0 3.1 "Entrez Gene: FBXL7 F-box and leucine-rich repeat protein 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23194.
Further reading
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. 2003. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. 1999. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
- "cDNA cloning and expression analysis of new members of the mammalian F-box protein family.". Genomics 67 (1): 40–7. 2001. doi:10.1006/geno.2000.6211. PMID 10945468.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. 2004. doi:10.1073/pnas.0307700101. PMID 15070733. Bibcode: 2004PNAS..101.4419W.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon.". Hum. Mol. Genet. 14 (16): 2289–303. 2005. doi:10.1093/hmg/ddi233. PMID 16000324.
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