Biology:FBXO7
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F-box only protein 7 is a protein that in humans is encoded by the FBXO7 gene.[1][2][3][4] Mutations in FBXO7 have been associated with Parkinson's disease.[5][6]
Function
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.[4]
Interactions
FBXO7 has been shown to interact with SKP1A,[7] CUL1,[1][8] CDK6,[9] p27,[9] PI31,[8] Parkin,[10] and PINK1.[10]
References
- ↑ 1.0 1.1 "Identification of a family of human F-box proteins". Current Biology 9 (20): 1177–9. October 1999. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
- ↑ "A family of mammalian F-box proteins". Current Biology 9 (20): 1180–2. October 1999. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
- ↑ "FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome". Neurology 72 (3): 240–5. January 2009. doi:10.1212/01.wnl.0000338144.10967.2b. PMID 19038853.
- ↑ 4.0 4.1 "Entrez Gene: FBXO7 F-box protein 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25793.
- ↑ "Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays". American Journal of Human Genetics 82 (6): 1375–84. June 2008. doi:10.1016/j.ajhg.2008.05.005. PMID 18513678.
- ↑ "FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome". Neurology 72 (3): 240–5. January 2009. doi:10.1212/01.wnl.0000338144.10967.2b. PMID 19038853.
- ↑ "Identification of a family of human F-box proteins". Current Biology 9 (20): 1177–9. October 1999. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
- ↑ 8.0 8.1 "Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor". The Journal of Biological Chemistry 283 (32): 22325–35. August 2008. doi:10.1074/jbc.M709900200. PMID 18495667.
- ↑ 9.0 9.1 "Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6". The EMBO Journal 24 (17): 3104–16. September 2005. doi:10.1038/sj.emboj.7600775. PMID 16096642.
- ↑ 10.0 10.1 "The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy". Nature Neuroscience 16 (9): 1257–65. September 2013. doi:10.1038/nn.3489. PMID 23933751.
Further reading
- "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. December 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. March 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics 67 (1): 40–7. July 2000. doi:10.1006/geno.2000.6211. PMID 10945468.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. November 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma". Oncogene 22 (2): 298–307. January 2003. doi:10.1038/sj.onc.1206129. PMID 12527899.
- "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Research 13 (1): 27–36. January 2003. doi:10.1101/gr.695703. PMID 12529303.
- "Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region". The Journal of Biological Chemistry 279 (31): 32592–602. July 2004. doi:10.1074/jbc.M404950200. PMID 15145941.
- "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology 5 (10): R84. 2005. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. October 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. January 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination". Biochemical and Biophysical Research Communications 342 (4): 1022–6. April 2006. doi:10.1016/j.bbrc.2006.02.061. PMID 16510124. http://ntur.lib.ntu.edu.tw/bitstream/246246/196424/1/902.pdf.
- "The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2". Molecular and Cellular Biology 26 (8): 3114–23. April 2006. doi:10.1128/MCB.26.8.3114-3123.2006. PMID 16581786.
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