Biology:FBXW2
 Generic protein structure example |
F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the FBXW2 gene.[1][2][3]
Function
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.[3]
Interactions
FBXW2 has been shown to interact with SKP1A.[1]
References
- ↑ 1.0 1.1 "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. Dec 1999. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. Bibcode: 1999CBio....9.1177C.
- ↑ "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet Cell Genet 88 (3–4): 255–8. Jun 2000. doi:10.1159/000015532. PMID 10828603.
- ↑ 3.0 3.1 "Entrez Gene: FBXW2 F-box and WD repeat domain containing 2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=26190.
Further reading
- "Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis". Trends Genet. 14 (6): 236–43. 1998. doi:10.1016/S0168-9525(98)01473-5. PMID 9635407.
- "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. 1999. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. Bibcode: 1999CBio....9.1180W.
- "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature 426 (6962): 87–91. 2003. doi:10.1038/nature02082. PMID 14603323. Bibcode: 2003Natur.426...87B.
- "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. 2004. doi:10.1073/pnas.0307700101. PMID 15070733. Bibcode: 2004PNAS..101.4419W.
- "FBW2 targets GCMa to the ubiquitin-proteasome degradation system". J. Biol. Chem. 280 (11): 10083–90. 2005. doi:10.1074/jbc.M413986200. PMID 15640526.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
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