Biology:FCER1G

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide is a protein that in humans is encoded by the FCER1G gene.

Function

The high affinity IgE receptor, FcεRI, is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008].

Further reading

• "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". The Journal of Biological Chemistry 272 (38): 23528–31. September 1997. doi:10.1074/jbc.272.38.23528. PMID 9295288. 
• "Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor". The Journal of Biological Chemistry 269 (35): 22427–32. September 1994. doi:10.1016/S0021-9258(17)31807-0. PMID 8071371. 
• "Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia". Hematology 17 (2): 71–5. March 2012. doi:10.1179/102453312X13221316477895. PMID 22664044. 
• "Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness". Clinical and Experimental Allergy 37 (4): 592–8. April 2007. doi:10.1111/j.1365-2222.2007.02680.x. PMID 17430357. 
• "Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia". Journal of Hematology & Oncology 5: 74. December 2012. doi:10.1186/1756-8722-5-74. PMID 23228155. 
• "Cooperative regulation of Fc receptor gamma-chain gene expression by multiple transcription factors, including Sp1, GABP, and Elf-1". The Journal of Biological Chemistry 283 (22): 15134–41. May 2008. doi:10.1074/jbc.M800498200. PMID 18378679. 
• "CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl". Journal of Immunology 189 (2): 786–92. July 2012. doi:10.4049/jimmunol.1200887. PMID 22706086. 
• "Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets". European Journal of Biochemistry 263 (3): 612–23. August 1999. doi:10.1046/j.1432-1327.1999.00560.x. PMID 10469124. 
• "Association between reduced levels of total serum IgE and FcepsilonRI expression in non-releaser basophils". Immunobiology 214 (5): 377–83. 2009. doi:10.1016/j.imbio.2008.09.008. PMID 19362683. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.