Biology:FEZ2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene.[1][2]
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.[2]
Interactions
FEZ2 has been shown to interact with Protein kinase Mζ.[3]
References
- ↑ "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A 94 (7): 3414–9. May 1997. doi:10.1073/pnas.94.7.3414. PMID 9096408. Bibcode: 1997PNAS...94.3414B.
- ↑ 2.0 2.1 "Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9637.
- ↑ Fujita, Toshitsugu; Ikuta Junko; Hamada Juri; Okajima Toshihide; Tatematsu Kenji; Tanizawa Katsuyuki; Kuroda Shun'ichi (Jan 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. (United States) 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. ISSN 0006-291X. PMID 14697253.
Further reading
- "Identification of human pre-T/NK cell-associated genes". J. Immunol. 151 (10): 5810–21. 1993. doi:10.4049/jimmunol.151.10.5810. PMID 8228263.
- "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis". Mech. Dev. 90 (2): 181–93. 2000. doi:10.1016/S0925-4773(99)00248-8. PMID 10642437.
- "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. 2000. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry 42 (51): 15369–76. 2004. doi:10.1021/bi034575v. PMID 14690447.
- "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3): 738–44. 2004. doi:10.1016/j.bbrc.2003.12.006. PMID 14697253.
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
- "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. 2006. doi:10.1074/jbc.M513280200. PMID 16484223.
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