Biology:FFAR2-FFAR3 receptor heteromer

From HandWiki
free fatty acid receptor 2
Identifiers
SymbolFFAR2
Alt. symbolsGPR43, FFA2R
NCBI gene2867
HGNC4501
OMIM603823
RefSeqNM_005306
UniProtO15552
Other data
LocusChr. 19 q13.1
free fatty acid receptor 3
Identifiers
SymbolFFAR3
Alt. symbolsGPR41, FFA3R
NCBI gene2865
HGNC4499
OMIM603821
RefSeqNM_005304
UniProtO14843
Other data
LocusChr. 19 q13.1

The FFAR2–FFAR3 receptor heteromer is a receptor heteromer consisting of free fatty acid receptors, FFAR2 and FFAR3 protomers.

Signal transduction

The signalling of the FFAR2-FFAR3 receptor heteromer is distinct from that of the parent receptor homomers. The FFAR2-FFAR3 heteromer displays enhanced intracellular calcium release and Arrestin beta 2 recruitment. The heteromer also lacks the ability to inhibit the cAMP-dependent pathway but gained the ability to induce P38 mitogen-activated protein kinases.[1]

References

  1. ↑ "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". FASEB Journal 32 (1): 289–303. January 2018. doi:10.1096/fj.201700252RR. PMID 28883043. PMC 5731126. http://www.fasebj.org/content/early/2017/09/07/fj.201700252RR. 




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