Biology:Free fatty acid receptor 3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Free fatty acid receptor 3 (FFA3) is a G-protein coupled receptor that in humans is encoded by the FFAR3 gene.[1][2] It is a member of the free fatty acid receptors group of receptors.
Animal studies
Knockout mouse studies have implicated FFAR3 in diabetes,[3] colitis,[4] hypertension[5] and asthma.[6] However, discrepancies between the pathways activated by FFAR3 agonists in human cells and the equivalent murine counterparts have been observed.[7]
Heteromerization
FFAR3 may interact with FFAR2 to form a FFAR2-FFAR3 receptor heteromer with signalling that is distinct from the parent homomers.[8]
See also
References
- ↑ "Entrez Gene: FFAR3 free fatty acid receptor 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2865.
- ↑ "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1". Biochemical and Biophysical Research Communications 239 (2): 543–7. October 1997. doi:10.1006/bbrc.1997.7513. PMID 9344866.
- ↑ "Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes". Nature Medicine 21 (2): 173–7. February 2015. doi:10.1038/nm.3779. PMID 25581519.
- ↑ "Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice". Gastroenterology 145 (2): 396–406.e1–10. August 2013. doi:10.1053/j.gastro.2013.04.056. PMID 23665276.
- ↑ "Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41". Physiological Genomics 48 (11): 826–834. November 2016. doi:10.1152/physiolgenomics.00089.2016. PMID 27664183.
- ↑ "Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis". Nature Medicine 20 (2): 159–66. February 2014. doi:10.1038/nm.3444. PMID 24390308.
- ↑ "Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists". Scientific Reports 6: 34145. September 2016. doi:10.1038/srep34145. PMID 27667443.
- ↑ "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". FASEB Journal 32 (1): –201700252RR. September 2017. doi:10.1096/fj.201700252RR. PMID 28883043. PMC 5731126. http://www.fasebj.org/content/early/2017/09/07/fj.201700252RR.
Further reading
- "A family of fatty acid binding receptors". DNA and Cell Biology 24 (1): 54–61. January 2005. doi:10.1089/dna.2005.24.54. PMID 15684720.
- "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids". The Journal of Biological Chemistry 278 (13): 11312–9. March 2003. doi:10.1074/jbc.M211609200. PMID 12496283.
- "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation". The Journal of Biological Chemistry 278 (28): 25481–9. July 2003. doi:10.1074/jbc.M301403200. PMID 12711604.
- "Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41". Proceedings of the National Academy of Sciences of the United States of America 101 (4): 1045–50. January 2004. doi:10.1073/pnas.2637002100. PMID 14722361.
- "Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line". Cellular Signalling 19 (1): 185–93. January 2007. doi:10.1016/j.cellsig.2006.06.004. PMID 16887331.
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