Biology:FGF7

Generic protein structure example

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.

Interactions

FGF7 has been shown to interact with Perlecan.

Further reading

• "Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair". The Journal of Investigative Dermatology. Symposium Proceedings 5 (1): 34–9. Dec 2000. doi:10.1046/j.1087-0024.2000.00009.x. PMID 11147673. 
• "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair". American Journal of Physiology. Lung Cellular and Molecular Physiology 282 (5): L924–40. May 2002. doi:10.1152/ajplung.00439.2001. PMID 11943656. 
• Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Advances in Cancer Research. 91. 2004. pp. 69–136. doi:10.1016/S0065-230X(04)91003-2. ISBN 978-0-12-006691-9. https://archive.org/details/advancesincancer0000unse_n0p5/page/69. 
• "Expression cloning of a human dual-specificity phosphatase". Proceedings of the National Academy of Sciences of the United States of America 89 (24): 12170–4. Dec 1992. doi:10.1073/pnas.89.24.12170. PMID 1281549. Bibcode: 1992PNAS...8912170I. 
• "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity". Annals of the New York Academy of Sciences 638: 62–77. 1992. doi:10.1111/j.1749-6632.1991.tb49018.x. PMID 1664700. 
• "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth". Science 245 (4919): 752–5. Aug 1989. doi:10.1126/science.2475908. PMID 2475908. Bibcode: 1989Sci...245..752F. https://zenodo.org/record/1230998. 
• "Purification and characterization of a newly identified growth factor specific for epithelial cells". Proceedings of the National Academy of Sciences of the United States of America 86 (3): 802–6. Feb 1989. doi:10.1073/pnas.86.3.802. PMID 2915979. Bibcode: 1989PNAS...86..802R. 
• "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor". The Journal of Biological Chemistry 268 (8): 5388–94. Mar 1993. doi:10.1016/S0021-9258(18)53334-2. PMID 7680645. 
• "Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy". Molecular and Cellular Biology 13 (8): 4513–22. Aug 1993. doi:10.1128/MCB.13.8.4513. PMID 7687739. 
• "The function of KGF in morphogenesis of epithelium and reepithelialization of wounds". Science 266 (5186): 819–22. Nov 1994. doi:10.1126/science.7973639. PMID 7973639. Bibcode: 1994Sci...266..819W. 
• "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea". Investigative Ophthalmology & Visual Science 34 (8): 2544–61. Jul 1993. PMID 8392040. 
• "Keratinocyte growth factor is required for hair development but not for wound healing". Genes & Development 10 (2): 165–75. Jan 1996. doi:10.1101/gad.10.2.165. PMID 8566750. 
• "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry 271 (25): 15292–7. Jun 1996. doi:10.1074/jbc.271.25.15292. PMID 8663044. 
• "Keratinocyte growth factor and its receptor are involved in regulating early lung branching". Development 122 (10): 3107–15. Oct 1996. doi:10.1242/dev.122.10.3107. PMID 8898224. 
• "Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans". Proceedings of the National Academy of Sciences of the United States of America 94 (21): 11461–5. Oct 1997. doi:10.1073/pnas.94.21.11461. PMID 9326632. Bibcode: 1997PNAS...9411461Z. 
• "Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries". Journal of Cellular Physiology 173 (3): 380–6. Dec 1997. doi:10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G. PMID 9369951. 
• "Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps". The Annals of Otology, Rhinology, and Laryngology 107 (10 Pt 1): 885–90. Oct 1998. doi:10.1177/000348949810701013. PMID 9794620. 
• "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry 275 (10): 7095–100. Mar 2000. doi:10.1074/jbc.275.10.7095. PMID 10702276.